Mycotoxin biosynthesis reviewed

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Molecular biology of mycotoxin biosynthesis.

Mycotoxins are secondary metabolites produced by many important phytopathogenic and food spoilage fungi including Aspergillus, Fusarium and Penicillium species. The toxicity of four of the most agriculturally important mycotoxins (the trichothecenes, and the polyketide-derived mycotoxins; aflatoxins, fumonisins and sterigmatocystin) are discussed and their chemical structure described. The step...

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Jan Carlo Barca and Y. Ahmet Sekercioglu Robotica / Volume 31 / Issue 03 / May 2013, pp 345 ­ 359 DOI: 10.1017/S026357471200032X, Published online: 03 July 2012 Link to this article: http://journals.cambridge.org/abstract_S026357471200032X How to cite this article: Jan Carlo Barca and Y. Ahmet Sekercioglu (2013). Swarm robotics reviewed. Robotica, 31, pp 345­359 doi:10.1017/ S026357471200032X R...

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SnPKS19 Encodes the Polyketide Synthase for Alternariol Mycotoxin Biosynthesis in the Wheat Pathogen Parastagonospora nodorum.

Alternariol (AOH) is an important mycotoxin from the Alternaria fungi. AOH was detected for the first time in the wheat pathogen Parastagonospora nodorum in a recent study. Here, we exploited reverse genetics to demonstrate that SNOG_15829 (SnPKS19), a close homolog of Penicillium aethiopicum norlichexanthone (NLX) synthase gene gsfA, is required for AOH production. We further validate that SnP...

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Structural reorganization of the fungal endoplasmic reticulum upon induction of mycotoxin biosynthesis

Compartmentalization of metabolic pathways to particular organelles is a hallmark of eukaryotic cells. Knowledge of the development of organelles and attendant pathways under different metabolic states has been advanced by live cell imaging and organelle specific analysis. Nevertheless, relatively few studies have addressed the cellular localization of pathways for synthesis of fungal secondary...

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Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS–PKS hybrid enzyme

Tenuazonic acid (TeA) is a well-known mycotoxin produced by various plant pathogenic fungi. However, its biosynthetic gene has been unknown to date. Here we identify the TeA biosynthetic gene from Magnaporthe oryzae by finding two TeA-inducing conditions of a low-producing strain. We demonstrate that TeA is synthesized from isoleucine and acetoacetyl-coenzyme A by TeA synthetase 1 (TAS1). TAS1 ...

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ژورنال

عنوان ژورنال: Nature

سال: 1981

ISSN: 0028-0836,1476-4687

DOI: 10.1038/290532b0